COBRE CCRD Director and Principal Investigator
Bharat Ramratnam, MD, is the principal investigator of the COBRE and heads the Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Warren Alpert Medical School, Brown University. Ramratnam received his medical degree from Brown University and completed a postdoctoral fellowship at Aaron Diamond AIDS Research Center, Rockefeller University, NY. Ramratnam's research focus is on defining the key cellular components that impact the replication of viruses such as HIV-1, herpes simplex virus (HSV) one and two, influenza and hepatitis B/C.
My interest in translational medical science began with a postdoctoral fellowship at Aaron Diamond AIDS Research Center, Rockefeller University after which I established my laboratory at Brown University. My interests have been in studying the RNA interference pathway as it intersects with basic biologic processes such as viral latency, intracellular communication and neoplastic transformation. I am particularly interested in translational studies that bridge the lab and clinic and enjoy collaborating with clinicians and basic scientists.
I mentor junior faculty and students in my capacity as core director in centers that focus on HIV-1 (Lifespan/Tufts/Brown CFAR), alcohol addiction (Brown Alcohol Research Center on HIV) and stem cell biology (Center for Stem Cell Research). I am the principal investigator of the COBRE Center for Cancer Research.
Selected Peer-reviewed Publications
Zhang Y, Gao JS, Tang X, Tucker LD, Quesenberry P, Rigoutsos I, Ramratnam B. MicroRNA 125a and its regulation of the p53 tumor suppressor gene. FEBS Lett. 2009 Nov 19;583(22):3725-30. Epub 2009 Oct 8. PMID: 19818772
Song Gao J, Zhang Y, Li M, Tucker LD, Machan JT, Quesenberry P, Rigoutsos I, Ramratnam B. Atypical transcription of microRNA gene fragments. Nucleic Acids Res. 2010 May;38(9):2775-87. Epub 2010 Jan 21. PMID: 20097657
Tang X, Zhang Y, Tucker L, Ramratnam B. Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization. Nucleic Acids Res. 2010 Oct 1;38(19):6610-9. Epub 2010 Jun 16. PMID: 20554852
Gao JS, Zhang Y, Tang X, Tucker LD, Tarwater PM, Quesenberry PJ, Rigoutsos I, Ramratnam B. The Evi1, microRNA-143, K-Ras axis in colon cancer. FEBS Lett. 2011 Feb 18;585(4):693-9. Epub 2011 Jan 26. PMID: 21276449
Tang X, Li M, Tucker L, Ramratnam B. Glycogen synthetase kinase β phosphorylates the RNAase III enzyme Drosha at Ser 300 and 302. Plos ONE, 2011;6(6):e20391. Epub 2011 Jun 3