Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair

Administration Core

Director: Qian Chen, PhD

Associate Director: J.J. Trey Crisco, PhD

The administration core is responsible for the planning, development, coordination and overall administration of the Center of Biomedical Research Excellence in Skeletal Health and Repair (COBRE SHR).

The specific aims for the administrative core are:

  1. Mentor junior faculties and organize COBRE enrichment programs including research seminars, multidisciplinary journal club, work-in-progress meetings and grant workshops.
  2. Facilitate and stimulate scientific interactions among projects and cores, coordinate research activities of the projects and cores, and promote collaboration with other Institutional Development Award (IDeA) programs in Rhode Island.
  3. Organize the meetings of the external advisory committee, which reviews the progress of each research project and selects pilot projects; and coordinate the meeting of the internal advisory committee, which provides guidance to developing external peer-reviewed center and/or program project grant applications.
  4. Prepare and maintain documentation relating to projects, cores and overall program management, implement resource sharing plan and maintain the communication with, and submit the appropriate progress reports to, the NIH.
  5. Educate COBRE investigators about the process of technology transfer and support the execution of technology transfer from COBRE investigators to commercial entities.
  6. Biostatistical support is provided by Jason Machan, PhD, director of the biostatistics core for Lifespan


Jason Machan, PhD is director of the Lifespan biostatistics core for Lifespan and assistant professor of orthopaedics and surgery at the Warren Alpert School of Medicine of Brown University. He also has an adjunct appointment in the department of psychology at the University of Rhode Island where he directs a biostatistics externship. While Machan's experience spans a wide range of biomedical fields, he has a long-standing and successful relationship with the department of orthopaedics, including collaborations on 20 peer-review manuscripts (out of more than 100) and six federally funded grants (out of 12). He serves on the editorial board of the Journal of Applied Biomechanics and reviews for Clinical Orthopaedics and Related Research, American Journal of Sports Medicine, Journal of Healthcare Engineering and Sports Health: A Multidisciplinary Approach.

Available Support

  • Scientific conceptualization and testable hypothesis development
  • Design and methodology, including data analysis plan and power analysis
  • Data management protocol development and REDCap database support
  • Assessment of mid-study design change implications on statistical analysis and inference
  • Data analysis
  • Write-up
  • Grant planning and writing

COBRE-SHR Activities

  • Attend and participate in COBRE-SHR meetings
  • Hold weekly office hours immediately following weekly COBRE-SHR research meetings
  • Actively engage with COBRE-SHR principle investigators and core directors
  • Ad-hoc collaborative meetings