Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair
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Bioengineering Core
Director: Braden Fleming, PhD
Associate Director: J.J. Trey Crisco, PhD
The bioengineering core provides the biomechanical expertise and resources to all of the past and future investigators comprising the Center of Biomedical Research Excellence (COBRE) in Skeletal Health and Repair at Rhode Island Hospital. The overall goal of this COBRE is to expand the multi-disciplinary research center that is focusing on the development, pathology and repair of cartilaginous tissues.
The specific aims of the bioengineering core are:
- To sustain and expand the bioengineering core facility to assist the COBRE scientists (past and present) in the design and implementation of biomechanical testing method.
- To continue to provide the resources (i.e. space, equipment and personnel) necessary to perform all of the biomechanical testing required by the COBRE projects.
- To expand the current platform to enhance the interaction among the project principal investigators, core directors and external resources relating to biomechanical testing and analyses.
- To extend the bioengineering services to the general hospital and university communities to make the bioengineering core self-sustainable.
Resources
- Biaxial ELF 3200 material test system (Bose Corp, Minnetonka, MN)
- Instron Electropuls E1000 (Instron Corp, Norwood, MA)
- Instron 8521S (Instron Corp, Norwood, MA)
- MTS Bionix Electromechanical Torsion System (MTS Systems Corp, Prairie Eden, MN)
- MTS 810 Material Test System (MTS Systems Corp, Prairie Eden, MN)
- MFP-3D-BIO atomic force microscope (Asylum Research, Santa Barbara, CA)
- Nikon TiU inverted microscope (Nikon Instruments, Melville, NY)
- Qualisys Oqus 5-Series (Qualisys, Gothenburg, Sweden)
- Optotrak System (Northern Digital Inc., Waterloo, Ontario)
- Keck XROMM Dual fluoroscopy system (custom, Brown University)
- Force plate Walkway (Tekscan, Boston, MA)
- I-scan (Tekscan, Boston, MA)
- Fuji Film Prescale Pressuregraph (FPD-901E, Fuji Photo Film Co Ltd, Tokyo, Japan)
- Active pendulum (small animal joint) (custom, Rhode Island Hospital)
- Passive pendulums (small and large animal joints)(custom, Rhode Island Hospital)
- Biaxial Loading Device - Tissue Engineering (custom, Rhode Island Hospital)
- Bio-Stretch Uniaxial System (ICCT Technologies, Canada)
- Tekscan High Resolution Walkway (HRV6)
Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair
- Faculty
- Cores
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COBRE Research
- Research Objectives
- Reverse Soaring Rates of Osteoarthritis
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Phase I Projects
- Mechanism of Growth Plate Development Regulated by HDAC4
- Endocrine and Nutritional Control of Long Bone Growth
- Mechanisms of Angiogenesis in Chondrosarcoma
- Assessment of Chondroprotection in ACL Injuries
- Cartilage Tissue Engineering for Joint Repair
- High-yield, Lineage-specific Enrichment of Living Mesenchymal Stem Cells
- Phase II Projects
- Technology Transfer
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