Infectious Diseases

Infectious Diseases Clinical Research

The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel.

We conduct trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C.

Other studies offered through our clinical trials unit include pharmaceutical studies to treat hepatitis C, prevent C. difficile infection, and test new methods of diagnosing HIV infection.

Currently Enrolling Research Studies

COVID-19 Studies

ACTIV-2/A5401 – Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID)

This study designed to evaluate the safety and efficacy of investigational agents, both infused and non-infused, for the treatment of symptomatic non-hospitalized adults with COVID-19.

Key Requirements

  • Ages 18 and above
  • Positive COVID-19 test within the past 10 days
  • Onset of symptoms within 8 days
  • Must have at least one currently occurring symptom

For more information, please visit: or call 877-345-8813

HIV Studies

Alcohol-HIV Study

This study designed to examine the effects of alcohol on the immune system and the brain.

Key Requirements

  • Ages 21-60
  • Able to consume alcohol safely
  • Able to consume nuts and soy safely
  • Able to attend 2 visits at the Brown School of Public Health
  • Free of metal devices or implants in the body


Project Preload

This study designed to examine a new way to help smokers with HIV quit smoking successfully by starting nicotine patch prior to the quit date.

Key Requirements

  • 18 years of age or older
  • Diagnosed with HIV
  • Daily smoker ready to quit smoking in the next month