Pediatric Hematology / Oncology
Hasbro Children's Hospital

Pediatric Hematology / Oncology Research

The Division of Pediatric Hematology and Oncology at Hasbro Children’s Hospital offers a wide array of clinical trials that bring the most advanced cancer and blood disorder treatments to the children of Rhode Island and neighboring Massachusetts and Connecticut. We believe that offering cutting-edge medical therapies to patients close to home is of utmost importance. In addition, we are advancing medical science by participating in numerous biology and scientific studies that will one day lead to a cure for childhood cancer and blood diseases.

Hasbro Children’s Hospital is a full member of the Children's Oncology Group as well as the Dana-Farber Acute Lymphoblastic Leukemia Consortium. In addition, we are founding members of both the Consortium for New England Childhood Cancer Survivors and the New England Pediatric Sickle Cell Consortium. Through these national and regional groups, we have novel therapies and new treatment protocols available for virtually every pediatric cancer patient, as well as for children dealing with chronic hematologic diseases or the long-term consequences of cancer treatment.

Precision Medicine and Research

Rishi Lulla, MD, MS and Bradley DeNardo, MD offer world class, research-driven medicine and clinical trials, delivered to patients diagnosed with pediatric cancer and blood disorders.

Children's Oncology Group

Hasbro Children’s Hospital is one of more than 200 leading children’s hospitals and cancer centers that is a member of the Children’s Oncology Group (COG). COG is a National Cancer Institute supported group that develops clinical trials for the treatment of nearly all types of childhood cancer. The active clinical trials offered through COG and available at Hasbro Children’s Hospital include front-line treatment for many types of childhood cancers, and trials for patients with relapsed cancer involving new and emerging treatments, including immunotherapy.

Dana Farber ALL Consortium

The DFCI ALL Consortium is an international collaborative group of pediatric and adult cancer centers, led by Dana-Farber Cancer Institute, that specializes in the treatment and study of acute lymphoblastic leukemia (ALL). ALL is the most common type of cancer diagnosed in children. With our most current treatment approaches, newly diagnosed ALL is one of the most curable cancers of childhood. The DFCI ALL Consortium has performed a series of clinical trials for children with ALL since its inception in 1981. Through these trials we have witnessed a significant improvement in our ability to cure ALL. Hasbro Children’s Hospital has been an active member of the DFCI/ALL Consortium since 2007. Through our collaborative work and membership in the consortium we remain at the forefront of treatment for pediatric ALL and are able to offer our newly diagnosed ALL patients the most current clinical trials and therapies for this disease.

Go With The Flow Yoga Study

Hasbro Children’s Hospital is conducting a research study to understand more about how yoga can impact quality of life for survivors of childhood, adolescent, and young adult cancer, as well as their siblings. Participants must be between the ages of 10- and 21-years-old.  E-mail for more information. 

Active Research Studies

Below is a list of all active research studies for which the Division of Pediatric Hematology and Oncology at Hasbro Children’s Hospital is currently enrolling participants.

For more information about these studies and how to participate, please contact us at 401-444-4673. For general information about clinical trials please visit the National Cancer Institute. For more information about each study, click a link below to visit that study's webpage. 

Leukemia and Lymphoma

Dana-Farber ALL Consortium Protocol 16-001: Treatment of Newly Diagnosed ALL in Children and Adolescents

AALL05B1, A Children’s Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens

AALL08B1, Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)

AALL1131, A Phase III Randomized Trial for Newly Diagnosed High Risk B-Lymphoblastic Leukemia (B-ALL) Including a Stratum Evaluating Dasatinib (IND# 73789, NSC# 606869) in Patients with Ph-like Tyrosine Kinase Inhibitor (TKI) Sensitive Mutations

AALL1331: Risk-Stratified Randomized Phase III Testing of Blinatumomab (IND#117467, NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)

AAML1331: A Phase III Study for Patients with Newly Diagnosed Acute Promyelocytic Leukemia (APL) using Arsenic Trioxide and All-Trans Retinoic Acid

AAML1531: Risk-stratified Therapy for Acute Myeloid Leukemia in Down Syndrome 

AHOD1331: A Randomized Phase III Study of Brentuximab Vedotin (SGN-35, IND#117117) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Adolescents

ANHL1131 - Intergroup Trial for Children or Adolescents with B-cell Non-Hodgkin Lymphoma NHL or Mature B-cell Leukemia B- AL: Evaluation of Rituximab (IND #10385) Efficacy and Safety in High Risk Patients

ANHL 12P1 A Randomized Phase II Trial of Brentuximab Vedotin (SGN35, NSC# 749710) or Crizotinib (NSC#749005, commercially labeled) in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma (ALCL) IND #117117

APEC1621: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)